First Week on Semaglutide GLP-1: How Your Body May Respond

At Set Point Medical Weight Loss Clinic, your health and comfort are our top priorities as you begin your semaglutide journey. Semaglutide, a GLP-1 receptor agonist, is an effective medication for both type 2 diabetes and weight management, and our medical team will be with you every step of the way.

During the first week on semaglutide GLP-1, most people notice changes in appetite before anything else. It’s common to feel fuller faster, have a reduced desire to snack, or experience a lower overall interest in food. Some people may see a small amount of weight loss simply because they’re eating less, but this varies widely. You might also notice mild digestive changes—nausea, softer stools, constipation, or a bit of bloating—as your body adjusts to the medication. These effects are usually temporary and tend to ease as you continue treatment.

Energy levels during the first week can vary. Some people feel slightly more tired, while others feel no change at all. Hydration becomes more important, especially if appetite drops or digestive side effects appear. Overall, the first week is mostly an adjustment period rather than a week of dramatic results. The medication’s full weight-loss effects typically build gradually over the following weeks. If side effects feel severe or don’t improve, it’s best to check in with your healthcare provider.

At Set Point Medical Weight Loss Clinic, your provider will give you detailed instructions on how to take semaglutide GLP-1. We’ll show you how to administer the shot safely and how to rotate injection sites to keep your skin healthy. Our experienced team is here to answer your questions, provide guidance, and help you achieve your healthiest weight in a safe and supportive environment.

When starting semaglutide (a GLP-1 agonist), some people may notice a slight reduction in weight during the first week, though the changes tend to be modest. Semaglutide GLP-1 works by reducing appetite and increasing feelings of fullness, which can help people cut down on calorie intake. This early effect may lead to some initial weight loss, especially if it’s combined with a healthy diet and exercise routine. However, the first week is typically more about the body adjusting to the medication rather than seeing significant changes on the scale.

The more substantial weight loss usually becomes evident after a few weeks, as the medication’s effects fully take hold. Over time, users may experience a more gradual and consistent reduction in weight as semaglutide GLP-1 continues to suppress appetite and help manage blood sugar levels. Everyone responds differently to the medication, so while some may see quick results, for others, the changes may be slower and more gradual.

Remember, sustainable weight loss is a gradual process. Patience and consistency are key. If you have questions or concerns about your progress on semaglutide GLP-1, our experienced healthcare providers at Set Point Medical Weight Loss Clinic are here to guide you every step of the way and adjust your plan as needed for the best results.

At Set Point Medical Weight Loss Clinic, we understand that starting a new weight loss program can be both exciting and challenging. It is normal not to lose much (or any) weight during the first week of semaglutide GLP-1 treatment. In the initial stages, your body is adjusting to the medication, and weight loss may take some time to become noticeable.

Semaglutide GLP-1 works by regulating appetite and improving insulin sensitivity, but its full effects typically become evident after several weeks of use. Some patients may also experience mild side effects, such as nausea or digestive discomfort, which can temporarily affect their appetite and food intake. During this period, focusing on healthy habits like balanced eating and regular physical activity is essential for long-term success. Although immediate weight loss may not be seen in the first week, consistent commitment to the program will support lasting, sustainable weight loss over time.

At Set Point Medical Weight Loss Clinic, we emphasise that healthy, sustainable weight loss is a gradual process. Rather than focusing only on the number on the scale during your first week, look for other positive changes—like increased energy, better sleep, or improved mood—that show your body is responding to your personalized plan. We are committed to helping you achieve lasting results and are always available to provide guidance and encouragement as you move forward on your weight loss journey.

At Set Point Medical Weight Loss Clinic, we are committed to supporting your journey with semaglutide GLP-1, a proven GLP-1 receptor agonist for medical weight loss. During your first week of treatment, adopting healthy lifestyle habits can help maximise your results and minimise side effects.

Here’s how you can set yourself up for success:

1. Eat Smaller, Balanced Meals

Semaglutide GLP-1 can slow gastric emptying and increase feelings of fullness. To help your body adjust, we recommend eating smaller, well-balanced meals throughout the day. Focus on high-fibre foods such as vegetables, fruits, and whole grains to aid digestion and help regulate blood sugar levels.

2. Stay Hydrated

Drink plenty of water daily to support your metabolism and reduce the risk of nausea—a common side effect when starting semaglutide GLP-1. Proper hydration also helps your body process nutrients effectively.

3. Engage in Regular Physical Activity

Our team at Set Point encourages you to incorporate moderate activities like walking, cycling, or swimming into your weekly routine. Consistency is more important than intensity, especially if you’re new to exercise. Physical activity works synergistically with semaglutide GLP-1 to promote weight loss and improve glucose regulation.

4. Watch Portion Sizes and Food Choices

Monitor your portion sizes and steer clear of high-fat, greasy, or overly sweet foods, as these can increase the likelihood of gastrointestinal discomfort. Our nutrition specialists are here to provide personalized meal planning if you need additional guidance.

5. Limit Alcohol Intake

Alcohol can worsen GI symptoms and interfere with blood sugar control while on semaglutide GLP-1. We advise minimising or avoiding alcohol during your treatment for the best results.

6. Create a Consistent Medication Routine

Take your semaglutide GLP–1 at the same time each week to establish a habit and ensure consistent effectiveness. Set reminders or speak with our staff if you need help developing a medication schedule.

7. Track Your Progress

Keep a log of your food intake, physical activity, and any symptoms you experience. Sharing this information with your Set Point Medical Weight Loss Clinic provider during follow-up visits will allow us to make informed adjustments to your treatment plan and support your long-term success.

Our team at Set Point Medical Weight Loss Clinic is here to support you every step of the way. Together, we can help you achieve your health and weight loss goals safely and effectively.

Troy Watson’s approach to starting semaglutide GLP-1 at Set Point Medical is designed to ensure each patient gets the best possible start on their weight loss journey. During the first week, patients may experience a gradual adjustment as their body begins to regulate appetite and improve insulin sensitivity. Troy Watson works closely with each patient to monitor their response to semaglutide GLP-1, offering personalised guidance on managing any initial side effects, such as mild nausea or digestive changes. His goal is to ensure patients feel supported and confident as they begin to see the benefits of this effective treatment.

Throughout the first week and beyond, Troy Watson provides continuous support, offering tailored advice on nutrition, exercise, and lifestyle changes to complement the effects of semaglutide GLP-1. He regularly assesses each patient’s progress, adjusting the dosage or treatment plan as necessary to maximise results and minimise any discomfort. Troy’s focus on individualised care ensures that patients not only get the most out of their semaglutide GLP-1 treatment but also have the tools and knowledge needed to achieve sustainable, long-term weight loss success.

For more information, contact us or schedule an appointment online. We have convenient locations to serve you in Folsom, CA and Roseville, CA. We serve patients from Folsom CA, Roseville CA, El Dorado Hills CA, Citrus Heights CA, Fair Oaks CA, Granite Bay CA, Rocklin CA, Rancho Cordova CA, Loomis CA, and surrounding areas.